This volume presents a detailed urban planning proposition focused on the eastern sector of Naples, exploring the shift from the city’s central nucleus toward the orient-zone as a strategic axis of transformation. The author combines city-regeneration, infrastructural development, and land-use policy to propose modifications to the city’s 1995 Piano Regolatore Generale (1995) framework. Emphasis is placed on the rehabilitation of industrial and degraded zones, the rethinking of transport corridors and the expansion of green infrastructure. The work contributes to the discourse on post-industrial urbanism, especially in southern European metropolitan contexts, by setting out a spatial-strategic vision guided by both ecological and socio-economic considerations.