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This inaugural annual volume of a mid-twentieth-century medical journal is dedicated to orthopedics and musculoskeletal medicine. As Year I (1950), it establishes the editorial and scientific orientation of the periodical, presenting clinical studies, surgical case reports, and theoretical discussions on trauma, deformities, and joint disorders. The publication reflects early postwar efforts to systematize orthopedic research within an academic framework, integrating anatomical investigation with operative practice. Intended for orthopedic surgeons and medical specialists, it documents the institutional development of orthopedic science in Italy..