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This volume of a prewar medical journal is dedicated to orthopedic and musculoskeletal surgery, under the scientific leadership of Vittorio Putti. Volume XXI (1935) reflects early twentieth-century approaches to trauma treatment, deformity correction, and joint disease management within the locomotor system. The articles combine anatomical study, surgical technique exposition, and clinical case documentation, illustrating the formative stage of modern orthopedic specialization. Intended for surgeons and academic physicians, the publication documents the institutional and methodological foundations of Italian orthopedic science before World War II.